Seroatlas · Human Serome Atlas

TRGV11

Probable non-functional T cell receptor gamma variable 11

Also known as: TCRGV11, TVG11_HUMAN, V4P

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A075B6L2
Gene
TRGV11
Ensembl
ENSG00000211693
Chromosome
7
Canonical length
119 aa
Protein class
Predicted intracellular proteins, T-cell receptor genes
Quaternary structure
Homodimer

OverviewNCBI Gene

Predicted to be involved in adaptive immune response. Predicted to be located in external side of plasma membrane. Predicted to be part of T cell receptor complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

119 residues, UniProt reviewed canonical sequence.

>A0A075B6L2|TRGV11
     1  MPLVVAVIFF SLWVFALGQL EQPEISISRP ANKSAHISWK ASIQGFSSKI IHWYWQKPNK
    61  GLEYLLHVFL TISAQDCSGG KTKKLEVSKN AHTSTSTLKI KFLEKEDEVV YHCACWIRH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRGV11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Highest tissue expression
0.5 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 0.5 nTPM
  • epididymis: 0.4 nTPM
  • spleen: 0.3 nTPM
  • lymph node: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM

Single-cell type

  • nk-cells: 0.1 nCPM
  • prostatic glandular cells: 0.1 nCPM
  • t-cells: 0.1 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM

Immune cell

  • gdT-cell: 2.9 nTPM
  • MAIT T-cell: 0.4 nTPM
  • memory CD8 T-cell: 0.1 nTPM
  • naive CD8 T-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM

Brain region

  • pons: 0.1 nTPM
  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRGV11 as an antibody target. Whether an autoantibody or antibody against TRGV11 could matter depends on whether native TRGV11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRGV11 is annotated at the cell surface, where native TRGV11 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TRGV11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRGV11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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