TRGV10
Probable non-functional T cell receptor gamma variable 10
Also known as: TCRGV10, TVG10_HUMAN, V3P
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A0A0MS01
- Gene
- TRGV10
- Ensembl
- ENSG00000211694
- Chromosome
- 7
- Canonical length
- 119 aa
- Protein class
- Predicted intracellular proteins, T-cell receptor genes
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Predicted to be involved in adaptive immune response. Predicted to be located in plasma membrane. Predicted to be part of T cell receptor complex. Predicted to be active in external side of plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
119 residues, UniProt reviewed canonical sequence.
>A0A0A0MS01|TRGV10
1 MSLLEAFAFS SWALGLGLSK VEQFQLSIST EVKKSIDIPC KISSTRFETD VIHWYRQKPN
61 QALEHLIYIV STKSAARRSM GKTSNKVEAR KNSQTLTSIL TIKSVEKEDM AVYYCAAWDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TRGV10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 13 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 13 nTPM
- spleen: 13 nTPM
- thymus: 12 nTPM
- lymph node: 10 nTPM
- prostate: 5.7 nTPM
- tonsil: 4.6 nTPM
Single-cell type
- t-cells: 11 nCPM
- nk-cells: 5.2 nCPM
- innate lymphoid cells: 3 nCPM
- gastric chief cells: 1.1 nCPM
- mucous neck cells: 0.8 nCPM
- salivary ionocytes: 0.4 nCPM
Immune cell
- gdT-cell: 197 nTPM
- naive CD8 T-cell: 160 nTPM
- MAIT T-cell: 156 nTPM
- memory CD8 T-cell: 138 nTPM
- memory CD4 T-cell: 47 nTPM
- total PBMC: 33 nTPM
Brain region
- choroid plexus: 1.3 nTPM
- basal ganglia: 0.7 nTPM
- medulla oblongata: 0.7 nTPM
- white matter: 0.7 nTPM
- cerebral cortex: 0.6 nTPM
- spinal cord: 0.6 nTPM
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TRGV10 as an antibody target. Whether an autoantibody or antibody against TRGV10 could matter depends on whether native TRGV10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TRGV10 is annotated at the cell surface, where native TRGV10 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label TRGV10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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