Seroatlas · Human Serome Atlas

TRGV1

Probable non-functional T cell receptor gamma variable

Also known as: TCRGV1, TRGV1_HUMAN, V1S1P

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A0A0MS02
Gene
TRGV1
Ensembl
ENSG00000211701
Chromosome
7
Canonical length
117 aa
Protein class
Predicted intracellular proteins, T-cell receptor genes
Quaternary structure
Homodimer

OverviewNCBI Gene

Predicted to be involved in adaptive immune response. Predicted to be located in plasma membrane. Predicted to be part of T cell receptor complex. Predicted to be active in external side of plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

117 residues, UniProt reviewed canonical sequence.

>A0A0A0MS02|TRGV1
     1  MRWALAVLLA FLSPASQISS NLEGRTKSVT RLTGSSAEIT CDLPGASTLY IHWYLHQEGK
    61  APQCLLYYEP YYSRVVLESG ITPGKYDTGS TRSNWNLRLQ NLIKNDSGFY YCATWDR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRGV1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Highest tissue expression
1.4 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 1.4 nTPM
  • lymph node: 1.3 nTPM
  • appendix: 0.5 nTPM
  • salivary gland: 0.5 nTPM
  • duodenum: 0.4 nTPM
  • bone marrow: 0.2 nTPM

Single-cell type

  • adipocytes: 1.7 nCPM
  • cardiomyocytes: 0.2 nCPM
  • cdc: 0.2 nCPM
  • macrophages: 0.2 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM

Immune cell

  • gdT-cell: 1.8 nTPM
  • MAIT T-cell: 1.8 nTPM
  • NK-cell: 1.7 nTPM
  • memory CD8 T-cell: 1.2 nTPM
  • memory CD4 T-cell: 0.8 nTPM
  • naive CD8 T-cell: 0.8 nTPM

Brain region

  • midbrain: 1.6 nTPM
  • medulla oblongata: 1.5 nTPM
  • white matter: 1.2 nTPM
  • thalamus: 1 nTPM
  • pons: 0.9 nTPM
  • spinal cord: 0.8 nTPM

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRGV1 as an antibody target. Whether an autoantibody or antibody against TRGV1 could matter depends on whether native TRGV1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRGV1 is annotated at the cell surface, where native TRGV1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TRGV1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRGV1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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