TRGJ1
T cell receptor gamma joining 1
Also known as: J1, TCRGJ1, TRGJ1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A075B6S0
- Gene
- TRGJ1
- Ensembl
- ENSG00000211690
- Chromosome
- 7
- Canonical length
- 16 aa
- Protein class
- Predicted intracellular proteins, T-cell receptor genes
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Predicted to be involved in adaptive immune response. Predicted to be located in plasma membrane. Predicted to be part of T cell receptor complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
16 residues, UniProt reviewed canonical sequence.
>A0A075B6S0|TRGJ1
1 NYYKKLFGSG TTLVVTLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TRGJ1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 46 nTPM
Expression across tissuesHPA
Tissue
- prostate: 46 nTPM
- bone marrow: 16 nTPM
- spleen: 12 nTPM
- lymph node: 4.5 nTPM
- small intestine: 4.2 nTPM
- duodenum: 3.1 nTPM
Single-cell type
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
- alveolar cells type 2: 0 nCPM
- astrocytes: 0 nCPM
Immune cell
- memory CD8 T-cell: 260 nTPM
- gdT-cell: 255 nTPM
- MAIT T-cell: 238 nTPM
- naive CD8 T-cell: 172 nTPM
- memory CD4 T-cell: 48 nTPM
- total PBMC: 44 nTPM
Brain region
- cerebral cortex: 16 nTPM
- amygdala: 7.7 nTPM
- white matter: 7 nTPM
- thalamus: 6.7 nTPM
- medulla oblongata: 5.7 nTPM
- midbrain: 5.7 nTPM
OntologyGO
Biological processes
Cellular components
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TRGJ1 as an antibody target. Whether an autoantibody or antibody against TRGJ1 could matter depends on whether native TRGJ1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TRGJ1 is annotated at the cell surface, where native TRGJ1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label TRGJ1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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