Seroatlas · Human Serome Atlas

TRGC2

T cell receptor gamma constant 2

Also known as: TRGC2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P03986
Gene: TRGC2
Canonical length: 189 aa
Protein class: Predicted membrane proteins, T-cell receptor genes
Quaternary structure: Homodimer

OverviewNCBI Gene

No narrative summary is available for TRGC2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

189 residues, UniProt reviewed canonical sequence.

>P03986|TRGC2
     1  DKQLDADVSP KPTIFLPSIA ETKLQKAGTY LCLLEKFFPD IIKIHWQEKK SNTILGSQEG
    61  NTMKTNDTYM KFSWLTVPEE SLDKEHRCIV RHENNKNGID QEIIFPPIKT DVTTVDPKYN
   121  YSKDANDVIT MDPKDNWSKD ANDTLLLQLT NTSAYYTYLL LLLKSVVYFA IITCCLLRRT
   181  AFCCNGEKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRGC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

thymus: 30 nTPM
spleen: 26 nTPM
bone marrow: 26 nTPM
prostate: 21 nTPM
lymph node: 15 nTPM
lung: 9.3 nTPM

Single-cell type

t-cells: 136 nCPM
nk-cells: 54 nCPM
neutrophil progenitors: 36 nCPM
thymocytes: 30 nCPM
monocyte progenitors: 24 nCPM
innate lymphoid cells: 22 nCPM

Immune cell

gdT-cell: 460 nTPM
memory CD8 T-cell: 299 nTPM
MAIT T-cell: 238 nTPM
naive CD8 T-cell: 185 nTPM
total PBMC: 123 nTPM
NK-cell: 96 nTPM

Brain region

thalamus: 6.3 nTPM
medulla oblongata: 5.4 nTPM
white matter: 5.4 nTPM
spinal cord: 4.9 nTPM
pons: 4.7 nTPM
basal ganglia: 4.1 nTPM

OntologyGO

Biological processes

Molecular functions

transmembrane signaling receptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRGC2 as an antibody target. Whether an autoantibody or antibody against TRGC2 could matter depends on whether native TRGC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRGC2 is annotated at the cell surface, where native TRGC2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TRGC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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