Seroatlas · Human Serome Atlas

TRGC1

T cell receptor gamma constant 1

Also known as: TRGC1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0CF51
Gene: TRGC1
Canonical length: 173 aa
Protein class: Predicted membrane proteins, T-cell receptor genes
Quaternary structure: Homodimer

OverviewNCBI Gene

No narrative summary is available for TRGC1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

173 residues, UniProt reviewed canonical sequence.

>P0CF51|TRGC1
     1  DKQLDADVSP KPTIFLPSIA ETKLQKAGTY LCLLEKFFPD VIKIHWQEKK SNTILGSQEG
    61  NTMKTNDTYM KFSWLTVPEK SLDKEHRCIV RHENNKNGVD QEIIFPPIKT DVITMDPKDN
   121  CSKDANDTLL LQLTNTSAYY MYLLLLLKSV VYFAIITCCL LRRTAFCCNG EKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRGC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Highest tissue expression: 39 nTPM

Expression across tissuesHPA

Tissue

prostate: 39 nTPM
bone marrow: 18 nTPM
spleen: 3.6 nTPM
thymus: 3 nTPM
lung: 1.7 nTPM
midbrain: 1.4 nTPM

Single-cell type

nk-cells: 17 nCPM
prostatic glandular cells: 16 nCPM
innate lymphoid cells: 8.6 nCPM
renal collecting duct intercalated cells: 8.6 nCPM
t-cells: 7.4 nCPM
neutrophil progenitors: 6.2 nCPM

Immune cell

gdT-cell: 60 nTPM
NK-cell: 18 nTPM
MAIT T-cell: 11 nTPM
memory CD8 T-cell: 5.2 nTPM
total PBMC: 4.7 nTPM
basophil: 3.2 nTPM

Brain region

thalamus: 1.3 nTPM
pons: 1 nTPM
amygdala: 0.8 nTPM
medulla oblongata: 0.8 nTPM
basal ganglia: 0.7 nTPM
midbrain: 0.7 nTPM

OntologyGO

Biological processes

Molecular functions

small molecule binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRGC1 as an antibody target. Whether an autoantibody or antibody against TRGC1 could matter depends on whether native TRGC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRGC1 is annotated at the cell surface, where native TRGC1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TRGC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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