TRBV7-9
T cell receptor beta variable 7-9
Also known as: TCRBV6S4A1, TCRBV7S9, TRBV79, TVB79_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P04435
- Gene
- TRBV7-9
- Ensembl
- ENSG00000278030
- Chromosome
- 7
- Canonical length
- 115 aa
- Protein class
- Predicted intracellular proteins, T-cell receptor genes
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Predicted to enable MHC protein binding activity and peptide antigen binding activity. Predicted to be involved in cell surface receptor signaling pathway. Predicted to be part of T cell receptor complex. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Canonical amino-acid sequenceUniProt
115 residues, UniProt reviewed canonical sequence.
>P04435|TRBV7-9
1 MGTSLLCWMA LCLLGADHAD TGVSQNPRHK ITKRGQNVTF RCDPISEHNR LYWYRQTLGQ
61 GPEFLTYFQN EAQLEKSRLL SDRFSAERPK GSFSTLEIQR TEQGDSAMYL CASSLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TRBV7-9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 51 nTPM
Expression across tissuesHPA
Tissue
- thymus: 51 nTPM
- lymph node: 25 nTPM
- tonsil: 15 nTPM
- spleen: 5 nTPM
- bone marrow: 3.9 nTPM
- gallbladder: 3.8 nTPM
Single-cell type
- late spermatids: 0.4 nCPM
- t-cells: 0.2 nCPM
- early spermatids: 0.1 nCPM
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
Immune cell
- T-reg: 95 nTPM
- memory CD8 T-cell: 82 nTPM
- naive CD8 T-cell: 74 nTPM
- naive CD4 T-cell: 68 nTPM
- memory CD4 T-cell: 49 nTPM
- total PBMC: 27 nTPM
Brain region
- cerebral cortex: 0.4 nTPM
- basal ganglia: 0.3 nTPM
- cerebellum: 0.3 nTPM
- medulla oblongata: 0.3 nTPM
- white matter: 0.3 nTPM
- amygdala: 0.2 nTPM
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TRBV7-9 as an antibody target. Whether an autoantibody or antibody against TRBV7-9 could matter depends on whether native TRBV7-9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TRBV7-9 is annotated at the cell surface, where native TRBV7-9 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label TRBV7-9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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