Seroatlas · Human Serome Atlas

TRBV7-3

Probable non-functional T cell receptor beta variable 7-3

Also known as: TCRBV6S1A1N1, TCRBV7S3, TRBV73, TVB73_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A075B6L6
Gene
TRBV7-3
Ensembl
ENSG00000211714
Chromosome
7
Canonical length
115 aa
Protein class
Predicted intracellular proteins, T-cell receptor genes
Quaternary structure
Homodimer

OverviewNCBI Gene

Predicted to be involved in cell surface receptor signaling pathway. Predicted to be part of T cell receptor complex. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

115 residues, UniProt reviewed canonical sequence.

>A0A075B6L6|TRBV7-3
     1  MGTRLLCWAA LCLLGADHTG AGVSQTPSNK VTEKGKDVEL RCDPISGHTA LYWYRQSLGQ
    61  GPEFLIYFQG TGAADDSGLP KDRFFAVRPE GSVSTLKIQR TEQGDSAAYL RASSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRBV7-3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Highest tissue expression
6.4 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 6.4 nTPM
  • testis: 2.6 nTPM
  • spleen: 1.8 nTPM
  • small intestine: 1.4 nTPM
  • esophagus: 0.8 nTPM
  • tonsil: 0.8 nTPM

Single-cell type

  • late spermatids: 16 nCPM
  • early spermatids: 13 nCPM
  • epididymal efferent duct absorptive cells: 0.4 nCPM
  • epididymal principal cells: 0.1 nCPM
  • innate lymphoid cells: 0.1 nCPM
  • leydig cells: 0.1 nCPM

Immune cell

  • memory CD4 T-cell: 32 nTPM
  • T-reg: 17 nTPM
  • naive CD8 T-cell: 10 nTPM
  • memory CD8 T-cell: 7.8 nTPM
  • naive CD4 T-cell: 7.4 nTPM
  • total PBMC: 5.2 nTPM

Brain region

  • basal ganglia: 0.2 nTPM
  • cerebral cortex: 0.2 nTPM
  • white matter: 0.2 nTPM
  • cerebellum: 0.1 nTPM
  • hypothalamus: 0.1 nTPM
  • medulla oblongata: 0.1 nTPM

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRBV7-3 as an antibody target. Whether an autoantibody or antibody against TRBV7-3 could matter depends on whether native TRBV7-3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRBV7-3 is annotated at the cell surface, where native TRBV7-3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TRBV7-3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRBV7-3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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