Seroatlas · Human Serome Atlas

TRBV6-8

T cell receptor beta variable 6-8

Also known as: TCRBV13S7P, TCRBV6S8, TRBV68, TVB68_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A0A6YYG3
Gene
TRBV6-8
Ensembl
ENSG00000253534
Chromosome
7
Canonical length
113 aa
Protein class
Predicted intracellular proteins, T-cell receptor genes
Quaternary structure
Homodimer

OverviewNCBI Gene

Predicted to be involved in cell surface receptor signaling pathway. Predicted to be part of T cell receptor complex. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

113 residues, UniProt reviewed canonical sequence.

>A0A0A6YYG3|TRBV6-8
     1  MSLGLLCCAA FSLLWAGPVN AGVTQTPKFH ILKTGQSMTL QCAQDMNHGY MSWYRQDPGM
    61  GLRLIYYSAA AGTTDKEVPN GYNVSRLNTE DFPLRLVSAA PSQTSVYLCA SSY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRBV6-8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Highest tissue expression
0.6 nTPM

Expression across tissuesHPA

Tissue

  • testis: 0.6 nTPM
  • thymus: 0.5 nTPM
  • appendix: 0.3 nTPM
  • lymph node: 0.2 nTPM
  • tonsil: 0.2 nTPM
  • adipose tissue: 0 nTPM

Single-cell type

  • late spermatids: 3 nCPM
  • early spermatids: 1.2 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM

Immune cell

  • naive CD4 T-cell: 1.1 nTPM
  • naive CD8 T-cell: 0.7 nTPM
  • MAIT T-cell: 0.4 nTPM
  • memory CD4 T-cell: 0.2 nTPM
  • memory CD8 T-cell: 0.1 nTPM
  • basophil: 0 nTPM

Brain region

  • cerebral cortex: 1 nTPM
  • basal ganglia: 0.6 nTPM
  • amygdala: 0.5 nTPM
  • white matter: 0.4 nTPM
  • cerebellum: 0.3 nTPM
  • pons: 0.3 nTPM

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRBV6-8 as an antibody target. Whether an autoantibody or antibody against TRBV6-8 could matter depends on whether native TRBV6-8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRBV6-8 is annotated at the cell surface, where native TRBV6-8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TRBV6-8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRBV6-8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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