TRBV6-7
Probable non-functional T cell receptor beta variable 6-7
Also known as: TCRBV13S8P, TCRBV6S7, TRBV67, TVB67_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A0A0MS04
- Gene
- TRBV6-7
- Ensembl
- ENSG00000253188
- Chromosome
- 7
- Canonical length
- 114 aa
- Protein class
- Predicted intracellular proteins, T-cell receptor genes
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Predicted to be involved in cell surface receptor signaling pathway. Predicted to be part of T cell receptor complex. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Canonical amino-acid sequenceUniProt
114 residues, UniProt reviewed canonical sequence.
>A0A0A0MS04|TRBV6-7
1 MSLGLLCCVA FSLLWAGPMN AGVTQTPKFH VLKTGQSMTL LCAQDMNHEY MYRYRQDPGK
61 GLRLIYYSVA AALTDKGEVP NGYNVSRSNT EDFPLKLESA APSQTSVYFC ASSYLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TRBV6-7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 1.5 nTPM
Expression across tissuesHPA
Tissue
- pancreas: 1.5 nTPM
- testis: 1.2 nTPM
- thymus: 1.2 nTPM
- lymph node: 0.3 nTPM
- bone marrow: 0.2 nTPM
- cerebral cortex: 0.1 nTPM
Single-cell type
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
- alveolar cells type 2: 0 nCPM
- astrocytes: 0 nCPM
Immune cell
- naive CD4 T-cell: 1.9 nTPM
- memory CD8 T-cell: 0.7 nTPM
- T-reg: 0.7 nTPM
- memory CD4 T-cell: 0.4 nTPM
- naive CD8 T-cell: 0.3 nTPM
- neutrophil: 0.3 nTPM
Brain region
- thalamus: 2.3 nTPM
- hippocampal formation: 1.4 nTPM
- amygdala: 0.9 nTPM
- cerebral cortex: 0.9 nTPM
- medulla oblongata: 0.9 nTPM
- pons: 0.9 nTPM
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TRBV6-7 as an antibody target. Whether an autoantibody or antibody against TRBV6-7 could matter depends on whether native TRBV6-7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TRBV6-7 is annotated at the cell surface, where native TRBV6-7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label TRBV6-7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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