TRBV5-4
T cell receptor beta variable 5-4
Also known as: TCRBV5S4, TCRBV5S6A3N2T, TRBV54, TVB54_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A0C4DH59
- Gene
- TRBV5-4
- Ensembl
- ENSG00000230099
- Chromosome
- 7
- Canonical length
- 114 aa
- Protein class
- Predicted intracellular proteins, T-cell receptor genes
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Predicted to be involved in cell surface receptor signaling pathway. Predicted to be part of T cell receptor complex. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Canonical amino-acid sequenceUniProt
114 residues, UniProt reviewed canonical sequence.
>A0A0C4DH59|TRBV5-4
1 MGPGLLCWAL LCLLGAGSVE TGVTQSPTHL IKTRGQQVTL RCSSQSGHNT VSWYQQALGQ
61 GPQFIFQYYR EEENGRGNFP PRFSGLQFPN YSSELNVNAL ELDDSALYLC ASSLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TRBV5-4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 21 nTPM
Expression across tissuesHPA
Tissue
- thymus: 21 nTPM
- pancreas: 11 nTPM
- lymph node: 7.7 nTPM
- tonsil: 7.5 nTPM
- appendix: 2.3 nTPM
- spleen: 2.1 nTPM
Single-cell type
- t-cells: 0.1 nCPM
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
- alveolar cells type 2: 0 nCPM
Immune cell
- T-reg: 116 nTPM
- naive CD4 T-cell: 63 nTPM
- memory CD4 T-cell: 50 nTPM
- naive CD8 T-cell: 37 nTPM
- memory CD8 T-cell: 27 nTPM
- total PBMC: 19 nTPM
Brain region
- basal ganglia: 0.8 nTPM
- medulla oblongata: 0.8 nTPM
- pons: 0.7 nTPM
- cerebral cortex: 0.6 nTPM
- amygdala: 0.4 nTPM
- cerebellum: 0.4 nTPM
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TRBV5-4 as an antibody target. Whether an autoantibody or antibody against TRBV5-4 could matter depends on whether native TRBV5-4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TRBV5-4 is annotated at the cell surface, where native TRBV5-4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label TRBV5-4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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