Seroatlas · Human Serome Atlas

TRBV5-3

Probable non-functional T cell receptor beta variable 5-3

Also known as: TCRBV5S3, TCRBV5S5P, TRBV53, TVB53_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A0A0MS03
Gene
TRBV5-3
Ensembl
ENSG00000211715
Chromosome
7
Canonical length
114 aa
Protein class
Predicted intracellular proteins, T-cell receptor genes
Quaternary structure
Homodimer

OverviewNCBI Gene

Predicted to be involved in cell surface receptor signaling pathway. Predicted to be part of T cell receptor complex. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

114 residues, UniProt reviewed canonical sequence.

>A0A0A0MS03|TRBV5-3
     1  MGPGLLCWEL LYLLGAGPVE AGVTQSPTHL IKTRGQQVTL RCSPISGHSS VSWYQQAPGQ
    61  GPQFIFEYAN ELRRSEGNFP NRFSGRQFHD YCSEMNVSAL ELGDSALYLC ARSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRBV5-3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Highest tissue expression
0.4 nTPM

Expression across tissuesHPA

Tissue

  • testis: 0.4 nTPM
  • thymus: 0.2 nTPM
  • pancreas: 0.1 nTPM
  • tonsil: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • astrocytes: 0 nCPM

Immune cell

  • MAIT T-cell: 2.7 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebral cortex: 0.2 nTPM
  • amygdala: 0.1 nTPM
  • basal ganglia: 0.1 nTPM
  • cerebellum: 0.1 nTPM
  • medulla oblongata: 0.1 nTPM
  • white matter: 0.1 nTPM

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRBV5-3 as an antibody target. Whether an autoantibody or antibody against TRBV5-3 could matter depends on whether native TRBV5-3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRBV5-3 is annotated at the cell surface, where native TRBV5-3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TRBV5-3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRBV5-3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...