TRBV4-2
T cell receptor beta variable 4-2
Also known as: TCRBV4S2, TCRBV7S3A2T, TRBV42, TVB42_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A539
- Gene
- TRBV4-2
- Ensembl
- ENSG00000211745
- Chromosome
- 7
- Canonical length
- 114 aa
- Protein class
- Predicted intracellular proteins, T-cell receptor genes
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Predicted to be involved in cell surface receptor signaling pathway. Predicted to be part of T cell receptor complex. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Canonical amino-acid sequenceUniProt
114 residues, UniProt reviewed canonical sequence.
>A0A539|TRBV4-2
1 MGCRLLCCAV LCLLGAVPME TGVTQTPRHL VMGMTNKKSL KCEQHLGHNA MYWYKQSAKK
61 PLELMFVYNF KEQTENNSVP SRFSPECPNS SHLFLHLHTL QPEDSALYLC ASSQLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TRBV4-2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 20 nTPM
Expression across tissuesHPA
Tissue
- thymus: 20 nTPM
- lymph node: 4.7 nTPM
- tonsil: 4.4 nTPM
- spleen: 2.1 nTPM
- small intestine: 1.4 nTPM
- appendix: 1.3 nTPM
Single-cell type
- late spermatids: 0.1 nCPM
- t-cells: 0.1 nCPM
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
Immune cell
- MAIT T-cell: 101 nTPM
- T-reg: 45 nTPM
- memory CD8 T-cell: 28 nTPM
- memory CD4 T-cell: 26 nTPM
- naive CD4 T-cell: 24 nTPM
- naive CD8 T-cell: 15 nTPM
Brain region
- cerebral cortex: 0.3 nTPM
- basal ganglia: 0.1 nTPM
- medulla oblongata: 0.1 nTPM
- white matter: 0.1 nTPM
- amygdala: 0 nTPM
- cerebellum: 0 nTPM
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TRBV4-2 as an antibody target. Whether an autoantibody or antibody against TRBV4-2 could matter depends on whether native TRBV4-2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TRBV4-2 is annotated at the cell surface, where native TRBV4-2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label TRBV4-2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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