TRBV30
T cell receptor beta variable 30
Also known as: TCRBV20S1A1N2, TCRBV30S1, TVB30_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A0K0K1B3
- Gene
- TRBV30
- Ensembl
- ENSG00000237254
- Chromosome
- 7
- Canonical length
- 111 aa
- Protein class
- Predicted intracellular proteins, T-cell receptor genes
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Predicted to be involved in cell surface receptor signaling pathway. Predicted to be part of T cell receptor complex. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Canonical amino-acid sequenceUniProt
111 residues, UniProt reviewed canonical sequence.
>A0A0K0K1B3|TRBV30
1 MLCSLLALLL GTFFGVRSQT IHQWPATLVQ PVGSPLSLEC TVEGTSNPNL YWYRQAAGRG
61 LQLLFYSVGI GQISSEVPQN LSASRPQDRQ FILSSKKLLL SDSGFYLCAW SLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TRBV30 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 24 nTPM
Expression across tissuesHPA
Tissue
- thymus: 24 nTPM
- tonsil: 13 nTPM
- lymph node: 10 nTPM
- spleen: 2.5 nTPM
- salivary gland: 2.3 nTPM
- bone marrow: 2 nTPM
Single-cell type
- basal keratinocytes: 0.2 nCPM
- urothelial cells: 0.2 nCPM
- breast hormone-responsive cells: 0.1 nCPM
- epididymal efferent duct absorptive cells: 0.1 nCPM
- t-cells: 0.1 nCPM
- adipocytes: 0 nCPM
Immune cell
- T-reg: 163 nTPM
- naive CD4 T-cell: 90 nTPM
- memory CD4 T-cell: 75 nTPM
- naive CD8 T-cell: 50 nTPM
- memory CD8 T-cell: 42 nTPM
- MAIT T-cell: 31 nTPM
Brain region
- basal ganglia: 1.1 nTPM
- cerebral cortex: 0.6 nTPM
- thalamus: 0.5 nTPM
- white matter: 0.5 nTPM
- amygdala: 0.2 nTPM
- hypothalamus: 0.2 nTPM
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TRBV30 as an antibody target. Whether an autoantibody or antibody against TRBV30 could matter depends on whether native TRBV30 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TRBV30 is annotated at the cell surface, where native TRBV30 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label TRBV30 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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