Seroatlas · Human Serome Atlas

TRBV28

T cell receptor beta variable 28

Also known as: TCRBV28S1, TCRBV3S1, TVB28_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A5B6
Gene
TRBV28
Ensembl
ENSG00000211753
Chromosome
7
Canonical length
114 aa
Protein class
Predicted intracellular proteins, T-cell receptor genes
Quaternary structure
Homodimer

OverviewNCBI Gene

Predicted to enable peptide antigen binding activity. Predicted to be involved in cell surface receptor signaling pathway. Predicted to be part of T cell receptor complex. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

114 residues, UniProt reviewed canonical sequence.

>A0A5B6|TRBV28
     1  MGIRLLCRVA FCFLAVGLVD VKVTQSSRYL VKRTGEKVFL ECVQDMDHEN MFWYRQDPGL
    61  GLRLIYFSYD VKMKEKGDIP EGYSVSREKK ERFSLILESA STNQTSMYLC ASSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRBV28 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Highest tissue expression
185 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 185 nTPM
  • tonsil: 32 nTPM
  • lymph node: 23 nTPM
  • spleen: 8.9 nTPM
  • appendix: 8.7 nTPM
  • urinary bladder: 4.9 nTPM

Single-cell type

  • t-cells: 4.8 nCPM
  • hematopoietic stem cells: 1.9 nCPM
  • thymocytes: 1.7 nCPM
  • early spermatids: 0.9 nCPM
  • cdc: 0.1 nCPM
  • innate lymphoid cells: 0.1 nCPM

Immune cell

  • T-reg: 155 nTPM
  • naive CD4 T-cell: 99 nTPM
  • memory CD4 T-cell: 95 nTPM
  • memory CD8 T-cell: 80 nTPM
  • naive CD8 T-cell: 54 nTPM
  • total PBMC: 34 nTPM

Brain region

  • cerebellum: 0.7 nTPM
  • basal ganglia: 0.6 nTPM
  • cerebral cortex: 0.5 nTPM
  • white matter: 0.4 nTPM
  • medulla oblongata: 0.2 nTPM
  • pons: 0.2 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRBV28 as an antibody target. Whether an autoantibody or antibody against TRBV28 could matter depends on whether native TRBV28 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRBV28 is annotated at the cell surface, where native TRBV28 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TRBV28 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRBV28. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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