TRBV24-1
T cell receptor beta variable 24-1
Also known as: TCRBV15S1, TCRBV24S1, TRBV241, TVBX1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A075B6N3
- Gene
- TRBV24-1
- Ensembl
- ENSG00000211750
- Chromosome
- 7
- Canonical length
- 115 aa
- Protein class
- Predicted intracellular proteins, T-cell receptor genes
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Predicted to be involved in cell surface receptor signaling pathway. Predicted to be part of T cell receptor complex. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Canonical amino-acid sequenceUniProt
115 residues, UniProt reviewed canonical sequence.
>A0A075B6N3|TRBV24-1
1 MASLLFFCGA FYLLGTGSMD ADVTQTPRNR ITKTGKRIML ECSQTKGHDR MYWYRQDPGL
61 GLQLIYYSFD VKDINKGEIS DGYSVSRQAQ AKFSLSLESA IPNQTALYFC ATSDLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TRBV24-1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 6.2 nTPM
Expression across tissuesHPA
Tissue
- thymus: 6.2 nTPM
- lymph node: 2.1 nTPM
- stomach: 1.5 nTPM
- spleen: 1.2 nTPM
- basal ganglia: 0.9 nTPM
- skeletal muscle: 0.9 nTPM
Single-cell type
- t-cells: 0.3 nCPM
- myonuclei: 0.2 nCPM
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
Immune cell
- naive CD8 T-cell: 27 nTPM
- T-reg: 23 nTPM
- memory CD4 T-cell: 16 nTPM
- memory CD8 T-cell: 16 nTPM
- naive CD4 T-cell: 11 nTPM
- gdT-cell: 9 nTPM
Brain region
- basal ganglia: 5.7 nTPM
- thalamus: 1.1 nTPM
- cerebral cortex: 0.9 nTPM
- white matter: 0.6 nTPM
- hippocampal formation: 0.5 nTPM
- amygdala: 0.4 nTPM
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TRBV24-1 as an antibody target. Whether an autoantibody or antibody against TRBV24-1 could matter depends on whether native TRBV24-1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TRBV24-1 is annotated at the cell surface, where native TRBV24-1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label TRBV24-1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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