Seroatlas · Human Serome Atlas

TRBV23-1

Probable non-functional T cell receptor beta variable 23-1

Also known as: TCRBV19S1P, TCRBV23S1, TRBV231, TVB23_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A0A0MS06
Gene
TRBV23-1
Ensembl
ENSG00000211749
Chromosome
7
Canonical length
115 aa
Protein class
Predicted intracellular proteins, T-cell receptor genes
Quaternary structure
Homodimer

OverviewNCBI Gene

Predicted to be involved in cell surface receptor signaling pathway. Predicted to be located in immunological synapse. Predicted to be part of T cell receptor complex. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

115 residues, UniProt reviewed canonical sequence.

>A0A0A0MS06|TRBV23-1
     1  MGTRLLGCAA LCLLAADSFH AKVTQTPGHL VKGKGQKTKM DCTPEKGHTF VYWYQQNQNK
    61  EFMLLISFQN EQVLQETEMH KKRFSSQCPK NAPCSLAILS SEPGDTALYL CASSQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRBV23-1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 11 nTPM
  • lymph node: 8.3 nTPM
  • tonsil: 5.5 nTPM
  • appendix: 3.2 nTPM
  • spleen: 2.3 nTPM
  • bone marrow: 2 nTPM

Single-cell type

  • müller glia: 0.2 nCPM
  • nk-cells: 0.2 nCPM
  • t-cells: 0.2 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM

Immune cell

  • T-reg: 1 nTPM
  • memory CD4 T-cell: 0.9 nTPM
  • MAIT T-cell: 0.8 nTPM
  • naive CD4 T-cell: 0.8 nTPM
  • memory CD8 T-cell: 0.5 nTPM
  • naive CD8 T-cell: 0.4 nTPM

Brain region

  • basal ganglia: 0.3 nTPM
  • cerebellum: 0.2 nTPM
  • cerebral cortex: 0.2 nTPM
  • white matter: 0.2 nTPM
  • hypothalamus: 0.1 nTPM
  • medulla oblongata: 0.1 nTPM

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRBV23-1 as an antibody target. Whether an autoantibody or antibody against TRBV23-1 could matter depends on whether native TRBV23-1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRBV23-1 is annotated at the cell surface, where native TRBV23-1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TRBV23-1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRBV23-1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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