Seroatlas · Human Serome Atlas

TRBV17

Probable non-functional T cell receptor beta variable 17

Also known as: TCRBV17S1, TCRBV26S1P, TVB17_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A087X0K7
Gene
TRBV17
Ensembl
ENSG00000277880
Chromosome
7
Canonical length
114 aa
Protein class
Predicted intracellular proteins, T-cell receptor genes
Quaternary structure
Homodimer

OverviewNCBI Gene

Predicted to be involved in cell surface receptor signaling pathway. Predicted to be part of T cell receptor complex. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

114 residues, UniProt reviewed canonical sequence.

>A0A087X0K7|TRBV17
     1  MDIWLLCWVT LCLLAAGHSE PGVSQTPRHK VTNMGQEVIL RCDPSSGHMF VHWYRQNLRQ
    61  EMKLLISFQY QNIAVDSGMP KERFTAERPN GTSSTLKIHP AEPRDSAVYL YSSG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRBV17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Highest tissue expression
0.2 nTPM

Expression across tissuesHPA

Tissue

  • testis: 0.2 nTPM
  • bone marrow: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM

Single-cell type

  • early spermatids: 0.1 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • basal ganglia: 0.2 nTPM
  • cerebral cortex: 0.2 nTPM
  • amygdala: 0.1 nTPM
  • cerebellum: 0.1 nTPM
  • white matter: 0.1 nTPM
  • choroid plexus: 0 nTPM

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRBV17 as an antibody target. Whether an autoantibody or antibody against TRBV17 could matter depends on whether native TRBV17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRBV17 is annotated at the cell surface, where native TRBV17 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TRBV17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRBV17. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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