Seroatlas · Human Serome Atlas

TRBV16

T cell receptor beta variable 16

Also known as: TCRBV16S1, TCRBV25S1A2PT, TVB16_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A087WV62
Gene
TRBV16
Ensembl
ENSG00000275243
Chromosome
7
Canonical length
115 aa
Protein class
Predicted intracellular proteins, T-cell receptor genes
Quaternary structure
Homodimer

OverviewNCBI Gene

Predicted to be involved in cell surface receptor signaling pathway. Predicted to be part of T cell receptor complex. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

115 residues, UniProt reviewed canonical sequence.

>A0A087WV62|TRBV16
     1  MSPIFTCITI LCLLAAGSPG EEVAQTPKHL VRGEGQKAKL YCAPIKGHSY VFWYQQVLKN
    61  EFKFLISFQN ENVFDETGMP KERFSAKCLP NSPCSLEIQA TKLEDSAVYF CASSQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRBV16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Highest tissue expression
1.3 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 1.3 nTPM
  • lymph node: 0.5 nTPM
  • testis: 0.5 nTPM
  • tonsil: 0.4 nTPM
  • lung: 0.2 nTPM
  • seminal vesicle: 0.1 nTPM

Single-cell type

  • early spermatids: 0.3 nCPM
  • late primary spermatocytes: 0.3 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM

Immune cell

  • T-reg: 5.8 nTPM
  • memory CD8 T-cell: 4.3 nTPM
  • memory CD4 T-cell: 2.6 nTPM
  • naive CD4 T-cell: 2.3 nTPM
  • total PBMC: 1.1 nTPM
  • naive CD8 T-cell: 0.8 nTPM

Brain region

  • cerebral cortex: 0.2 nTPM
  • basal ganglia: 0.1 nTPM
  • cerebellum: 0.1 nTPM
  • medulla oblongata: 0.1 nTPM
  • white matter: 0.1 nTPM
  • amygdala: 0 nTPM

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRBV16 as an antibody target. Whether an autoantibody or antibody against TRBV16 could matter depends on whether native TRBV16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRBV16 is annotated at the cell surface, where native TRBV16 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TRBV16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRBV16. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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