Seroatlas · Human Serome Atlas

TRBV13

T cell receptor beta variable 13

Also known as: TCRBV13S1, TCRBV23S1A2T, TVB13_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0A0A6YYD4
Gene: TRBV13
Ensembl: ENSG00000276405
Chromosome: 7
Canonical length: 124 aa
Protein class: Predicted intracellular proteins, T-cell receptor genes
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to be involved in cell surface receptor signaling pathway. Predicted to be part of T cell receptor complex. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

124 residues, UniProt reviewed canonical sequence.

>A0A0A6YYD4|TRBV13
     1  MLSPDLPDSA WNTRLLCRVM LCLLGAGSVA AGVIQSPRHL IKEKRETATL KCYPIPRHDT
    61  VYWYQQGPGQ DPQFLISFYE KMQSDKGSIP DRFSAQQFSD YHSELNMSSL ELGDSALYFC
   121  ASSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRBV13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

thymus: 29 nTPM
lymph node: 6.3 nTPM
tonsil: 3.7 nTPM
spleen: 1.9 nTPM
appendix: 1.5 nTPM
pancreas: 1.4 nTPM

Single-cell type

late spermatids: 1 nCPM
early spermatids: 0.4 nCPM
leydig cells: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM

Immune cell

naive CD8 T-cell: 21 nTPM
T-reg: 21 nTPM
memory CD8 T-cell: 13 nTPM
naive CD4 T-cell: 12 nTPM
memory CD4 T-cell: 7.9 nTPM
total PBMC: 4.5 nTPM

Brain region

hypothalamus: 0.4 nTPM
cerebral cortex: 0.3 nTPM
basal ganglia: 0.2 nTPM
white matter: 0.2 nTPM
amygdala: 0.1 nTPM
hippocampal formation: 0.1 nTPM

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRBV13 as an antibody target. Whether an autoantibody or antibody against TRBV13 could matter depends on whether native TRBV13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRBV13 is annotated at the cell surface, where native TRBV13 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TRBV13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...