Seroatlas · Human Serome Atlas

TRBV12-3

T cell receptor beta variable 12-3

Also known as: TCRBV12S3, TCRBV8S1, TRBV123, TVBL3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P01733
Gene
TRBV12-3
Ensembl
ENSG00000274752
Chromosome
7
Canonical length
115 aa
Protein class
Predicted intracellular proteins, T-cell receptor genes
Quaternary structure
Homodimer

OverviewNCBI Gene

Predicted to enable MHC protein binding activity and peptide antigen binding activity. Predicted to be involved in cell surface receptor signaling pathway. Predicted to be part of T cell receptor complex. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

115 residues, UniProt reviewed canonical sequence.

>P01733|TRBV12-3
     1  MDSWTFCCVS LCILVAKHTD AGVIQSPRHE VTEMGQEVTL RCKPISGHNS LFWYRQTMMR
    61  GLELLIYFNN NVPIDDSGMP EDRFSAKMPN ASFSTLKIQP SEPRDSAVYF CASSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRBV12-3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Highest tissue expression
57 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 57 nTPM
  • lymph node: 13 nTPM
  • tonsil: 12 nTPM
  • appendix: 4.1 nTPM
  • spleen: 3.6 nTPM
  • bone marrow: 2.2 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • astrocytes: 0 nCPM

Immune cell

  • T-reg: 46 nTPM
  • naive CD4 T-cell: 33 nTPM
  • memory CD4 T-cell: 29 nTPM
  • naive CD8 T-cell: 24 nTPM
  • memory CD8 T-cell: 15 nTPM
  • total PBMC: 10 nTPM

Brain region

  • basal ganglia: 0.1 nTPM
  • cerebellum: 0.1 nTPM
  • cerebral cortex: 0.1 nTPM
  • choroid plexus: 0.1 nTPM
  • medulla oblongata: 0.1 nTPM
  • spinal cord: 0.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TRBV12-3.

Disease | ImmuneIEDB

Conditions an epitope on TRBV12-3 was assayed in.

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRBV12-3 as an antibody target. Whether an autoantibody or antibody against TRBV12-3 could matter depends on whether native TRBV12-3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRBV12-3 is annotated at the cell surface, where native TRBV12-3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TRBV12-3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRBV12-3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...