Seroatlas · Human Serome Atlas

TRBV11-2

T cell receptor beta variable 11-2

Also known as: TVBK2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0A584
Gene: TRBV11-2
Canonical length: 115 aa
Quaternary structure: Homodimer

OverviewNCBI Gene

No narrative summary is available for TRBV11-2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

115 residues, UniProt reviewed canonical sequence.

>A0A584|TRBV11-2
     1  MGTRLLCWAA LCLLGAELTE AGVAQSPRYK IIEKRQSVAF WCNPISGHAT LYWYQQILGQ
    61  GPKLLIQFQN NGVVDDSQLP KDRFSAERLK GVDSTLKIQP AKLEDSAVYL CASSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRBV11-2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRBV11-2 as an antibody target. Whether an autoantibody or antibody against TRBV11-2 could matter depends on whether native TRBV11-2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRBV11-2 is annotated at the cell surface, where native TRBV11-2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TRBV11-2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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