TRBV10-1
T cell receptor beta variable 10-1
Also known as: TCRBV10S1, TCRBV12S2, TCRBV12S2A1T, TRBV101, TVBJ1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A0K0K1A3
- Gene
- TRBV10-1
- Ensembl
- ENSG00000211717
- Chromosome
- 7
- Canonical length
- 114 aa
- Protein class
- Predicted intracellular proteins, T-cell receptor genes
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Predicted to be involved in cell surface receptor signaling pathway. Predicted to be part of T cell receptor complex. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Canonical amino-acid sequenceUniProt
114 residues, UniProt reviewed canonical sequence.
>A0A0K0K1A3|TRBV10-1
1 MGTRLFFYVA LCLLWAGHRD AEITQSPRHK ITETGRQVTL ACHQTWNHNN MFWYRQDLGH
61 GLRLIHYSYG VHDTNKGEVS DGYSVSRSNT EDLPLTLESA ASSQTSVYFC ASSELocalizationUniProt · AlphaFold · HPA
Whether an antibody against TRBV10-1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 4.1 nTPM
Expression across tissuesHPA
Tissue
- thymus: 4.1 nTPM
- appendix: 0.4 nTPM
- lymph node: 0.4 nTPM
- small intestine: 0.3 nTPM
- pancreas: 0.2 nTPM
- spleen: 0.2 nTPM
Single-cell type
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
- alveolar cells type 2: 0 nCPM
- astrocytes: 0 nCPM
Immune cell
- T-reg: 9.5 nTPM
- naive CD4 T-cell: 6.2 nTPM
- memory CD4 T-cell: 4.7 nTPM
- MAIT T-cell: 3.2 nTPM
- memory CD8 T-cell: 3 nTPM
- naive CD8 T-cell: 2.6 nTPM
Brain region
- basal ganglia: 0.2 nTPM
- cerebral cortex: 0.2 nTPM
- amygdala: 0.1 nTPM
- pons: 0.1 nTPM
- white matter: 0.1 nTPM
- cerebellum: 0 nTPM
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TRBV10-1 as an antibody target. Whether an autoantibody or antibody against TRBV10-1 could matter depends on whether native TRBV10-1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TRBV10-1 is annotated at the cell surface, where native TRBV10-1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label TRBV10-1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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