TRBJ2-5
T cell receptor beta joining 2-5
Also known as: TJB25_HUMAN
Protein identityUniProt · HPA
- UniProt accession
- A0A0A0MTA4
- Gene
- TRBJ2-5
- Canonical length
- 15 aa
- Protein class
- Predicted intracellular proteins, T-cell receptor genes
- Quaternary structure
- Homodimer
OverviewNCBI Gene
No narrative summary is available for TRBJ2-5 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
15 residues, UniProt reviewed canonical sequence.
>A0A0A0MTA4|TRBJ2-5
1 QETQYFGPGT RLLVLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TRBJ2-5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 10 nTPM
Expression across tissuesHPA
Tissue
- spleen: 10 nTPM
- lymph node: 9.3 nTPM
- appendix: 8.6 nTPM
- thymus: 8.5 nTPM
- stomach: 6.2 nTPM
- tonsil: 5.9 nTPM
Single-cell type
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
- alveolar cells type 2: 0 nCPM
- astrocytes: 0 nCPM
Immune cell
- T-reg: 1,105 nTPM
- naive CD4 T-cell: 666 nTPM
- memory CD4 T-cell: 587 nTPM
- memory CD8 T-cell: 391 nTPM
- naive CD8 T-cell: 356 nTPM
- total PBMC: 282 nTPM
Brain region
- cerebral cortex: 2.7 nTPM
- basal ganglia: 2.4 nTPM
- thalamus: 2.2 nTPM
- hippocampal formation: 2 nTPM
- white matter: 1.6 nTPM
- hypothalamus: 1.4 nTPM
OntologyGO
Biological processes
Cellular components
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TRBJ2-5 as an antibody target. Whether an autoantibody or antibody against TRBJ2-5 could matter depends on whether native TRBJ2-5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TRBJ2-5 is annotated at the cell surface, where native TRBJ2-5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label TRBJ2-5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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