TRBJ2-4
T cell receptor beta joining 2-4
Also known as: TJB24_HUMAN
Protein identityUniProt · HPA
- UniProt accession
- A0A0A0MT87
- Gene
- TRBJ2-4
- Canonical length
- 16 aa
- Protein class
- Predicted intracellular proteins, T-cell receptor genes
- Quaternary structure
- Homodimer
OverviewNCBI Gene
No narrative summary is available for TRBJ2-4 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
16 residues, UniProt reviewed canonical sequence.
>A0A0A0MT87|TRBJ2-4
1 AKNIQYFGAG TRLSVLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TRBJ2-4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 18 nTPM
Expression across tissuesHPA
Tissue
- spleen: 18 nTPM
- thymus: 14 nTPM
- lymph node: 10 nTPM
- appendix: 9.6 nTPM
- bone marrow: 8.6 nTPM
- tonsil: 5.8 nTPM
Single-cell type
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
- alveolar cells type 2: 0 nCPM
- astrocytes: 0 nCPM
Immune cell
- T-reg: 487 nTPM
- gdT-cell: 242 nTPM
- naive CD4 T-cell: 237 nTPM
- memory CD4 T-cell: 229 nTPM
- naive CD8 T-cell: 216 nTPM
- naive B-cell: 197 nTPM
Brain region
- thalamus: 6.4 nTPM
- cerebral cortex: 3.9 nTPM
- white matter: 2.6 nTPM
- basal ganglia: 2.4 nTPM
- medulla oblongata: 1.7 nTPM
- amygdala: 1.1 nTPM
OntologyGO
Biological processes
Cellular components
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TRBJ2-4 as an antibody target. Whether an autoantibody or antibody against TRBJ2-4 could matter depends on whether native TRBJ2-4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TRBJ2-4 is annotated at the cell surface, where native TRBJ2-4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label TRBJ2-4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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