TRBJ2-3
T cell receptor beta joining 2-3
Also known as: TCRBJ2S3, TJB23_HUMAN, TRBJ23
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A0B4J200
- Gene
- TRBJ2-3
- Ensembl
- ENSG00000211767
- Chromosome
- 7
- Canonical length
- 16 aa
- Protein class
- Predicted intracellular proteins, T-cell receptor genes
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Predicted to be involved in adaptive immune response. Predicted to be located in plasma membrane. Predicted to be part of T cell receptor complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
16 residues, UniProt reviewed canonical sequence.
>A0A0B4J200|TRBJ2-3
1 STDTQYFGPG TRLTVLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TRBJ2-3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 82 nTPM
Expression across tissuesHPA
Tissue
- appendix: 82 nTPM
- lymph node: 77 nTPM
- spleen: 72 nTPM
- thymus: 54 nTPM
- tonsil: 49 nTPM
- small intestine: 21 nTPM
Single-cell type
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
- alveolar cells type 2: 0 nCPM
- astrocytes: 0 nCPM
Immune cell
- T-reg: 2,323 nTPM
- gdT-cell: 1,491 nTPM
- naive B-cell: 1,433 nTPM
- memory B-cell: 1,213 nTPM
- memory CD8 T-cell: 1,157 nTPM
- memory CD4 T-cell: 1,126 nTPM
Brain region
- thalamus: 43 nTPM
- midbrain: 19 nTPM
- cerebral cortex: 12 nTPM
- amygdala: 9.2 nTPM
- white matter: 8.4 nTPM
- spinal cord: 4.2 nTPM
OntologyGO
Biological processes
Cellular components
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TRBJ2-3 as an antibody target. Whether an autoantibody or antibody against TRBJ2-3 could matter depends on whether native TRBJ2-3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TRBJ2-3 is annotated at the cell surface, where native TRBJ2-3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label TRBJ2-3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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