Seroatlas · Human Serome Atlas

TRBJ2-2

T cell receptor beta joining 2-2

Also known as: TJB22_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A0A0MT94
Gene
TRBJ2-2
Canonical length
16 aa
Protein class
Predicted intracellular proteins, T-cell receptor genes
Quaternary structure
Homodimer

OverviewNCBI Gene

No narrative summary is available for TRBJ2-2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

16 residues, UniProt reviewed canonical sequence.

>A0A0A0MT94|TRBJ2-2
     1  NTGELFFGEG SRLTVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRBJ2-2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Highest tissue expression
29 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 29 nTPM
  • lymph node: 25 nTPM
  • bone marrow: 19 nTPM
  • appendix: 16 nTPM
  • tonsil: 14 nTPM
  • spleen: 12 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • astrocytes: 0 nCPM

Immune cell

  • T-reg: 724 nTPM
  • MAIT T-cell: 522 nTPM
  • naive CD4 T-cell: 390 nTPM
  • memory CD4 T-cell: 337 nTPM
  • memory CD8 T-cell: 333 nTPM
  • naive CD8 T-cell: 325 nTPM

Brain region

  • cerebral cortex: 3.6 nTPM
  • thalamus: 2.8 nTPM
  • basal ganglia: 1.9 nTPM
  • medulla oblongata: 1.8 nTPM
  • white matter: 1.6 nTPM
  • spinal cord: 1.3 nTPM

OntologyGO

Biological processes

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRBJ2-2 as an antibody target. Whether an autoantibody or antibody against TRBJ2-2 could matter depends on whether native TRBJ2-2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRBJ2-2 is annotated at the cell surface, where native TRBJ2-2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TRBJ2-2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRBJ2-2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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