TRBJ2-1
T cell receptor beta joining 2-1
Also known as: TCRBJ2S1, TJB21_HUMAN, TRBJ21
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A0A0MTA7
- Gene
- TRBJ2-1
- Ensembl
- ENSG00000211764
- Chromosome
- 7
- Canonical length
- 16 aa
- Protein class
- Predicted intracellular proteins, T-cell receptor genes
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Predicted to be involved in adaptive immune response. Predicted to be located in plasma membrane. Predicted to be part of T cell receptor complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
16 residues, UniProt reviewed canonical sequence.
>A0A0A0MTA7|TRBJ2-1
1 SYNEQFFGPG TRLTVLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TRBJ2-1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 62 nTPM
Expression across tissuesHPA
Tissue
- thymus: 62 nTPM
- lymph node: 39 nTPM
- tonsil: 34 nTPM
- spleen: 28 nTPM
- bone marrow: 26 nTPM
- appendix: 25 nTPM
Single-cell type
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
- alveolar cells type 2: 0 nCPM
- astrocytes: 0 nCPM
Immune cell
- T-reg: 1,691 nTPM
- memory CD8 T-cell: 1,184 nTPM
- naive CD4 T-cell: 917 nTPM
- memory CD4 T-cell: 909 nTPM
- naive CD8 T-cell: 891 nTPM
- MAIT T-cell: 538 nTPM
Brain region
- thalamus: 20 nTPM
- cerebral cortex: 8.3 nTPM
- midbrain: 6.1 nTPM
- basal ganglia: 5 nTPM
- amygdala: 3.5 nTPM
- pons: 2.1 nTPM
OntologyGO
Biological processes
Cellular components
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TRBJ2-1 as an antibody target. Whether an autoantibody or antibody against TRBJ2-1 could matter depends on whether native TRBJ2-1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TRBJ2-1 is annotated at the cell surface, where native TRBJ2-1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label TRBJ2-1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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