TRBJ1-3
T cell receptor beta joining 1-3
Also known as: TCRBJ1S3, TJB13_HUMAN, TRBJ13
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A0J9YWP8
- Gene
- TRBJ1-3
- Ensembl
- ENSG00000282133
- Chromosome
- 7
- Canonical length
- 16 aa
- Protein class
- Predicted intracellular proteins, T-cell receptor genes
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Predicted to be involved in adaptive immune response. Predicted to be located in plasma membrane. Predicted to be part of T cell receptor complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
16 residues, UniProt reviewed canonical sequence.
>A0A0J9YWP8|TRBJ1-3
1 SGNTIYFGEG SWLTVVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TRBJ1-3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 199 nTPM
Expression across tissuesHPA
Tissue
- thymus: 199 nTPM
- tonsil: 108 nTPM
- lymph node: 88 nTPM
- spleen: 49 nTPM
- appendix: 46 nTPM
- rectum: 16 nTPM
Single-cell type
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
- alveolar cells type 2: 0 nCPM
- astrocytes: 0 nCPM
Immune cell
- T-reg: 173 nTPM
- naive CD4 T-cell: 123 nTPM
- memory CD4 T-cell: 106 nTPM
- memory CD8 T-cell: 63 nTPM
- naive CD8 T-cell: 54 nTPM
- total PBMC: 45 nTPM
Brain region
- cerebral cortex: 3.1 nTPM
- basal ganglia: 2.6 nTPM
- thalamus: 2.4 nTPM
- medulla oblongata: 2.3 nTPM
- pons: 2.3 nTPM
- amygdala: 1.2 nTPM
OntologyGO
Biological processes
Cellular components
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TRBJ1-3 as an antibody target. Whether an autoantibody or antibody against TRBJ1-3 could matter depends on whether native TRBJ1-3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TRBJ1-3 is annotated at the cell surface, where native TRBJ1-3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label TRBJ1-3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...