Seroatlas · Human Serome Atlas

TRB

T cell receptor beta chain MC.7.G5

Also known as: TRBR2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DTU4
Gene: TRB
Canonical length: 315 aa
Quaternary structure: Homodimer

OverviewNCBI Gene

No narrative summary is available for TRB in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

315 residues, UniProt reviewed canonical sequence.

>P0DTU4|TRB
     1  MTIRLLCYMG FYFLGAGLME ADIYQTPRYL VIGTGKKITL ECSQTMGHDK MYWYQQDPGM
    61  ELHLIHYSYG VNSTEKGDLS SESTVSRIRT EHFPLTLESA RPSHTSQYLC ASSEARGLAE
   121  FTDTQYFGPG TRLTVLEDLK NVFPPEVAVF EPSEAEISHT QKATLVCLAT GFYPDHVELS
   181  WWVNGKEVHS GVSTDPQPLK EQPALNDSRY CLSSRLRVSA TFWQNPRNHF RCQVQFYGLS
   241  ENDEWTQDRA KPVTQIVSAE AWGRADCGFT SESYQQGVLS ATILYEILLG KATLYAVLVS
   301  ALVLMAMVKR KDSRG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.35

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TRB.

Disease | ImmuneIEDB

Conditions an epitope on TRB was assayed in.

prostate cancer B cell

OntologyGO

Biological processes

Molecular functions

signaling receptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRB as an antibody target. Whether an autoantibody or antibody against TRB could matter depends on whether native TRB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRB is annotated at the cell surface, where native TRB is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TRB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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