Seroatlas · Human Serome Atlas

TRAV35

T cell receptor alpha variable 35

Also known as: TVA35_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DPF4
Gene: TRAV35
Canonical length: 110 aa
Quaternary structure: Homodimer

OverviewNCBI Gene

No narrative summary is available for TRAV35 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

110 residues, UniProt reviewed canonical sequence.

>P0DPF4|TRAV35
     1  MLLEHLLIIL WMQLTWVSGQ QLNQSPQSMF IQEGEDVSMN CTSSSIFNTW LWYKQEPGEG
    61  PVLLIALYKA GELTSNGRLT AQFGITRKDS FLNISASIPS DVGIYFCAGQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRAV35 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0

OntologyGO

Biological processes

Cellular components

T cell receptor complex

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRAV35 as an antibody target. Whether an autoantibody or antibody against TRAV35 could matter depends on whether native TRAV35 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRAV35 is annotated at the cell surface, where native TRAV35 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TRAV35 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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