Seroatlas · Human Serome Atlas

TRAV1-2

T cell receptor alpha variable 1-2

Also known as: TVA12_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A0B4J238
Gene
TRAV1-2
Ensembl
ENSG00000256553
Chromosome
14
Canonical length
106 aa
Protein class
Predicted intracellular proteins, T-cell receptor genes
Quaternary structure
Homodimer

OverviewNCBI Gene

T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor alpha and delta loci. Both the alpha and delta loci include V (variable), J (joining), and C (constant) segments and the delta locus also includes diversity (D) segments. The delta locus is situated within the alpha locus, between the alpha V and J segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The alpha chain is synthesized by recombination joining a single V segment with a J segment. For both chains, the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. Five variable segments can be used in either alpha or delta chains and are described by TRAV/DV symbols. Several V and J segments of the alpha locus are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq, Aug 2016]

Canonical amino-acid sequenceUniProt

106 residues, UniProt reviewed canonical sequence.

>A0A0B4J238|TRAV1-2
     1  MWGVFLLYVS MKMGGTTGQN IDQPTEMTAT EGAIVQINCT YQTSGFNGLF WYQQHAGEAP
    61  TFLSYNVLDG LEEKGRFSSF LSRSKGYSYL LLKELQMKDS ASYLCA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRAV1-2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Highest tissue expression
18 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 18 nTPM
  • lymph node: 7.1 nTPM
  • tonsil: 6.7 nTPM
  • spleen: 4.3 nTPM
  • appendix: 4.2 nTPM
  • gallbladder: 2.8 nTPM

Single-cell type

  • t-cells: 0.3 nCPM
  • early primary spermatocytes: 0.1 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM

Immune cell

  • MAIT T-cell: 2,033 nTPM
  • memory CD8 T-cell: 312 nTPM
  • T-reg: 80 nTPM
  • naive CD8 T-cell: 70 nTPM
  • memory CD4 T-cell: 45 nTPM
  • naive CD4 T-cell: 41 nTPM

Brain region

  • medulla oblongata: 0.2 nTPM
  • pons: 0.2 nTPM
  • spinal cord: 0.2 nTPM
  • white matter: 0.2 nTPM
  • cerebral cortex: 0.1 nTPM
  • midbrain: 0.1 nTPM

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRAV1-2 as an antibody target. Whether an autoantibody or antibody against TRAV1-2 could matter depends on whether native TRAV1-2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRAV1-2 is annotated at the cell surface, where native TRAV1-2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TRAV1-2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRAV1-2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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