TRAPPC3L
Trafficking protein particle complex subunit 3-like protein
Also known as: bA259P20.2, BET3L, FLJ11180, TPC3L_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5T215
- Gene
- TRAPPC3L
- Ensembl
- ENSG00000173626
- Chromosome
- 6
- Canonical length
- 181 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Golgi apparatus,Vesicles
- Quaternary structure
- Homodimer
OverviewNCBI Gene
Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and intra-Golgi vesicle-mediated transport. Part of TRAPP complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
181 residues, UniProt reviewed canonical sequence.
>Q5T215|TRAPPC3L
1 MSRPAHRRPE YHKINKDLFV LTYGALVAQL CKDYEKDEDV NQYLDKMGYG IGTRLVEDFL
61 ARSCVGRCHS YSEIIDIIAQ VAFKMYLGIT PSVTCNNSSK NEFSLILEKN PLVEFVEELP
121 AGRSSLCYCN LLCGIIRGAL EMVHLAADVT FLQDRLKGDS VTEIGITFLK KRDEKKYRGK
181 KLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TRAPPC3L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.36
- Highest tissue expression
- 4.2 nTPM
Expression across tissuesHPA
Tissue
- spleen: 4.2 nTPM
- retina: 4.1 nTPM
- placenta: 3.6 nTPM
- bone marrow: 3 nTPM
- parathyroid gland: 2.8 nTPM
- skin: 1.9 nTPM
Single-cell type
- platelets: 147 nCPM
- kupffer cells: 11 nCPM
- epicardial cells: 4.5 nCPM
- late primary spermatocytes: 4.3 nCPM
- pericytes: 3.9 nCPM
- vascular endothelial cells: 3.6 nCPM
Immune cell
- total PBMC: 2.8 nTPM
- neutrophil: 0.8 nTPM
- basophil: 0.4 nTPM
- naive CD4 T-cell: 0.2 nTPM
- plasmacytoid DC: 0.2 nTPM
- classical monocyte: 0.1 nTPM
Brain region
- cerebellum: 48 nTPM
- cerebral cortex: 43 nTPM
- white matter: 40 nTPM
- basal ganglia: 37 nTPM
- pons: 35 nTPM
- thalamus: 35 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.51
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.66
- DepMap mean gene effect
- 0.09
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TRAPPC3L as an antibody target. Whether an autoantibody or antibody against TRAPPC3L could matter depends on whether native TRAPPC3L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TRAPPC3L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TRAPPC3L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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