Seroatlas · Human Serome Atlas

TRAC

T cell receptor alpha chain constant

Also known as: TRAC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P01848
Gene: TRAC
Ensembl: ENSG00000277734
Chromosome: 14
Canonical length: 140 aa
Protein class: Disease related genes, Predicted membrane proteins, T-cell receptor genes
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011]

Canonical amino-acid sequenceUniProt

140 residues, UniProt reviewed canonical sequence.

>P01848|TRAC
     1  IQNPDPAVYQ LRDSKSSDKS VCLFTDFDSQ TNVSQSKDSD VYITDKTVLD MRSMDFKSNS
    61  AVAWSNKSDF ACANAFNNSI IPEDTFFPSP ESSCDVKLVE KSFETDTNLN FQNLSVIGFR
   121  ILLLKVAGFN LLMTLRLWSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRAC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Highest tissue expression: 734 nTPM

Expression across tissuesHPA

Tissue

thymus: 734 nTPM
lymph node: 369 nTPM
tonsil: 269 nTPM
appendix: 149 nTPM
spleen: 126 nTPM
retina: 105 nTPM

Single-cell type

t-cells: 482 nCPM
innate lymphoid cells: 101 nCPM
rod photoreceptor cells: 59 nCPM
late primary spermatocytes: 57 nCPM
epididymal clear cells: 53 nCPM
nk-cells: 52 nCPM

Immune cell

T-reg: 4,392 nTPM
total PBMC: 2,967 nTPM
memory CD4 T-cell: 2,948 nTPM
naive CD4 T-cell: 2,681 nTPM
memory CD8 T-cell: 2,509 nTPM
naive CD8 T-cell: 2,395 nTPM

Brain region

basal ganglia: 31 nTPM
midbrain: 16 nTPM
cerebellum: 14 nTPM
amygdala: 11 nTPM
pons: 7.6 nTPM
medulla oblongata: 6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TRAC.

Disease | AllUniProt

Conditions TRAC is implicated in, by any mechanism.

Immunodeficiency 7 (IMD7) MIM:615387

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 1 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

TCR-alpha-beta-positive T-cell deficiency

Disease | ImmuneIEDB

Conditions an epitope on TRAC was assayed in.

rheumatoid arthritis B cell

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRAC as an antibody target. Whether an autoantibody or antibody against TRAC could matter depends on whether native TRAC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRAC is annotated at the cell surface, where native TRAC is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TRAC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...