Seroatlas · Human Serome Atlas

TRABD2B

Metalloprotease TIKI2

Also known as: TIKI2, TIKI2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NFA1
Gene: TRABD2B
Ensembl: ENSG00000269113
Chromosome: 1
Canonical length: 517 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Enables Wnt-protein binding activity and metalloendopeptidase activity. Involved in several processes, including negative regulation of Wnt signaling pathway; positive regulation of protein oxidation; and positive regulation of protein-containing complex assembly. Located in nucleoplasm; organelle membrane; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

517 residues, UniProt reviewed canonical sequence.

>A6NFA1|TRABD2B
     1  MHAALAGPLL AALLATARAR PQPPDGGQCR PPGSQRDLNS FLWTIRRDPP AYLFGTIHVP
    61  YTRVWDFIPD NSKAAFQAST RVYFELDLTD PYTISALASC QLLPHGENLQ DVLPHELYWR
   121  LKRHLDYVKL MMPSWMTPAQ RGKGLYADYL FNAIAGNWER KRPVWVMLMV NSLTERDVRF
   181  RGVPVLDLYL AQQAEKMKKT TGAVEQVEEQ CHPLNNGLNF SQVLFALNQT LLQQESVRAG
   241  SLQASYTTED LIKHYNCGDL SAVIFNHDTS QLPNFINTTL PPHEQVTAQE IDSYFRQELI
   301  YKRNERMGKR VMALLRENED KICFFAFGAG HFLGNNTVID ILRQAGLEVD HTPAGQAIHS
   361  PAPQSPAPSP EGTSTSPAPV TPAAAVPEAP SVTPTAPPED EDPALSPHLL LPDSLSQLEE
   421  FGRQRKWHKR QSTHQRPRQF NDLWVRIEDS TTASPPPLPL QPTHSSGTAK PPFQLSDQLQ
   481  QQDPPGPASS SAPTLGLLPA IATTIAVCFL LHSLGPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRABD2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 20 nTPM
kidney: 15 nTPM
heart muscle: 6.5 nTPM
liver: 3.9 nTPM
prostate: 3.3 nTPM
urinary bladder: 3.3 nTPM

Single-cell type

proximal tubule cells: 1,139 nCPM
distal convoluted tubule cells: 687 nCPM
renal connecting tubule cells: 650 nCPM
loop of henle epithelial cells: 228 nCPM
renal collecting duct principal cells: 133 nCPM
papillary tip epithelial cells: 132 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 2.1 nTPM
choroid plexus: 1.2 nTPM
basal ganglia: 0.4 nTPM
cerebral cortex: 0.4 nTPM
pons: 0.4 nTPM
white matter: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.42
gnomAD pLI: 0.84
gnomAD missense Z: 2.99
DepMap mean gene effect: -0.1
DepMap dependency class: selective

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRABD2B as an antibody target. Whether an autoantibody or antibody against TRABD2B could matter depends on whether native TRABD2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRABD2B is annotated at the cell surface, where native TRABD2B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TRABD2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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