Seroatlas · Human Serome Atlas

TRA

T cell receptor alpha chain MC.7.G5

Also known as: TRAR2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DTU3
Gene: TRA
Canonical length: 275 aa
Quaternary structure: Homodimer

OverviewNCBI Gene

No narrative summary is available for TRA in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

275 residues, UniProt reviewed canonical sequence.

>P0DTU3|TRA
     1  MACPGFLWAL VISTCLEFSM AQTVTQSQPE MSVQEAETVT LSCTYDTSES DYYLFWYKQP
    61  PSRQMILVIR QEAYKQQNAT ENRFSVNFQK AAKSFSLKIS DSQLGDAAMY FCAYRSAVNA
   121  RLMFGDGTQL VVKPNIQNPD PAVYQLRDSK SSDKSVCLFT DFDSQTNVSQ SKDSDVYITD
   181  KTVLDMRSMD FKSNSAVAWS NKSDFACANA FNNSIIPEDT FFPSPESSCD VKLVEKSFET
   241  DTNLNFQNLS VIGFRILLLK VAGFNLLMTL RLWSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.38

OntologyGO

Biological processes

Molecular functions

signaling receptor activity

Cellular components

alpha-beta T cell receptor complex

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRA in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

NCOA1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRA as an antibody target. Whether an autoantibody or antibody against TRA could matter depends on whether native TRA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRA is annotated at the cell surface, where native TRA is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TRA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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