Seroatlas · Human Serome Atlas

TPSD1

Tryptase delta

Also known as: TRYD_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BZJ3
Gene: TPSD1
Ensembl: ENSG00000095917
Chromosome: 16
Canonical length: 242 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Secretome location: Intracellular and membrane
Quaternary structure: Homotetramer

OverviewNCBI Gene

Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. Although this gene may be an exception, most of the tryptase genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. This gene was once considered to be a pseudogene, although it is now believed to be a functional gene that encodes a protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

242 residues, UniProt reviewed canonical sequence.

>Q9BZJ3|TPSD1
     1  MLLLAPQMLS LLLLALPVLA SPAYVAPAPG QALQQTGIVG GQEAPRSKWP WQVSLRVRGP
    61  YWMHFCGGSL IHPQWVLTAA HCVEPDIKDL AALRVQLREQ HLYYQDQLLP VSRIIVHPQF
   121  YIIQTGADIA LLELEEPVNI SSHIHTVTLP PASETFPPGM PCWVTGWGDV DNNVHLPPPY
   181  PLKEVEVPVV ENHLCNAEYH TGLHTGHSFQ IVRDDMLCAG SENHDSCQGD SGGPLVCKVN
   241  GT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TPSD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

stomach: 20 nTPM
lung: 17 nTPM
gallbladder: 13 nTPM
small intestine: 13 nTPM
urinary bladder: 12 nTPM
skin: 9 nTPM

Single-cell type

mast cells: 136 nCPM
bergmann glia: 4.6 nCPM
astrocytes: 3.1 nCPM
parietal cells: 1.8 nCPM
epididymal efferent duct ciliated cells: 0.4 nCPM
vascular smooth muscle cells: 0.4 nCPM

Immune cell

basophil: 2.9 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 1.6 nTPM
pons: 1.2 nTPM
thalamus: 1 nTPM
hippocampal formation: 0.9 nTPM
basal ganglia: 0.8 nTPM
cerebellum: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.85
gnomAD pLI: 0
gnomAD missense Z: -1.62
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proteolysis

Molecular functions

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TPSD1 as an antibody target. Whether an autoantibody or antibody against TPSD1 could matter depends on whether native TPSD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TPSD1 is annotated as secreted, so native TPSD1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label TPSD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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