Seroatlas · Human Serome Atlas

TPSB2

Tryptase beta-2

Also known as: TRYB2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P20231
Gene: TPSB2
Ensembl: ENSG00000197253
Chromosome: 16
Canonical length: 275 aa
Protein class: Enzymes, Metabolic proteins, Predicted secreted proteins
Secretome location: Secreted to blood
Quaternary structure: Homotetramer

OverviewNCBI Gene

Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, beta II and beta III. Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha-tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

275 residues, UniProt reviewed canonical sequence.

>P20231|TPSB2
     1  MLNLLLLALP VLASRAYAAP APGQALQRVG IVGGQEAPRS KWPWQVSLRV RDRYWMHFCG
    61  GSLIHPQWVL TAAHCVGPDV KDLAALRVQL REQHLYYQDQ LLPVSRIIVH PQFYTAQIGA
   121  DIALLELEEP VNVSSHVHTV TLPPASETFP PGMPCWVTGW GDVDNDERLP PPFPLKQVKV
   181  PIMENHICDA KYHLGAYTGD DVRIVRDDML CAGNTRRDSC QGDSGGPLVC KVNGTWLQAG
   241  VVSWGEGCAQ PNRPGIYTRV TYYLDWIHHY VPKKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TPSB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 141 nTPM

Expression across tissuesHPA

Tissue

small intestine: 141 nTPM
urinary bladder: 123 nTPM
lung: 122 nTPM
skin: 116 nTPM
stomach: 100 nTPM
gallbladder: 98 nTPM

Single-cell type

mast cells: 13,412 nCPM
pancreatic acinar cells: 27 nCPM
gastric chief cells: 21 nCPM
pancreatic islet cells: 14 nCPM
pancreatic duct cells: 9.2 nCPM
smooth muscle cells: 7.4 nCPM

Immune cell

basophil: 5 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 1.6 nTPM
basal ganglia: 0.9 nTPM
spinal cord: 0.7 nTPM
hippocampal formation: 0.6 nTPM
hypothalamus: 0.6 nTPM
pons: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.9
gnomAD pLI: 0
gnomAD missense Z: -2.04

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proteolysis

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TPSB2 as an antibody target. Whether an autoantibody or antibody against TPSB2 could matter depends on whether native TPSB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TPSB2 is annotated as secreted, so native TPSB2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label TPSB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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