Seroatlas · Human Serome Atlas

TPSAB1

Tryptase alpha/beta-1

Also known as: TPS1, TPS2, TPSB1, TRYB1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15661
Gene
TPSAB1
Ensembl
ENSG00000172236
Chromosome
16
Canonical length
275 aa
Protein class
Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted secreted proteins
Subcellular location
Vesicles
Secretome location
Secreted to blood
Quaternary structure
Homotetramer

OverviewNCBI Gene

Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, alpha and beta 1. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

275 residues, UniProt reviewed canonical sequence.

>Q15661|TPSAB1
     1  MLNLLLLALP VLASRAYAAP APGQALQRVG IVGGQEAPRS KWPWQVSLRV HGPYWMHFCG
    61  GSLIHPQWVL TAAHCVGPDV KDLAALRVQL REQHLYYQDQ LLPVSRIIVH PQFYTAQIGA
   121  DIALLELEEP VNVSSHVHTV TLPPASETFP PGMPCWVTGW GDVDNDERLP PPFPLKQVKV
   181  PIMENHICDA KYHLGAYTGD DVRIVRDDML CAGNTRRDSC QGDSGGPLVC KVNGTWLQAG
   241  VVSWGEGCAQ PNRPGIYTRV TYYLDWIHHY VPKKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TPSAB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
141 nTPM

Expression across tissuesHPA

Tissue

  • small intestine: 141 nTPM
  • lung: 123 nTPM
  • gallbladder: 122 nTPM
  • urinary bladder: 120 nTPM
  • skin: 116 nTPM
  • stomach: 101 nTPM

Single-cell type

  • mast cells: 8,487 nCPM
  • pancreatic acinar cells: 26 nCPM
  • tuft cells: 12 nCPM
  • megakaryocyte-erythroid progenitors: 11 nCPM
  • pancreatic islet cells: 10 nCPM
  • pancreatic duct cells: 8.9 nCPM

Immune cell

  • basophil: 90 nTPM
  • total PBMC: 1.7 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • choroid plexus: 1.3 nTPM
  • basal ganglia: 0.6 nTPM
  • pons: 0.6 nTPM
  • cerebral cortex: 0.3 nTPM
  • hippocampal formation: 0.3 nTPM
  • amygdala: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.95
gnomAD pLI
0
gnomAD missense Z
-3.13
DepMap mean gene effect
0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TPSAB1 as an antibody target. Whether an autoantibody or antibody against TPSAB1 could matter depends on whether native TPSAB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TPSAB1 is annotated as secreted, so native TPSAB1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label TPSAB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TPSAB1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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