Seroatlas · Human Serome Atlas

TPRXL

Tetra-peptide repeat homeobox-like protein

Also known as: TPRXL_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q17RH7
Gene: TPRXL
Canonical length: 139 aa

OverviewNCBI Gene

No narrative summary is available for TPRXL in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

139 residues, UniProt reviewed canonical sequence.

>Q17RH7|TPRXL
     1  MQDPRHPQGL PLSPGLPKRQ RQDRTIYNWK QQEVLENHFK EEQYPDYDTR QELAEMLNLR
    61  EYQVQVWFKN RRAKRSRERW FQKQLQQLQK HPQQQHPQQQ HPQQQLQQQQ PQQQPQQQQP
   121  QQQPQQQQPQ QQQLHQQPQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TPRXL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.29

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

maternal-to-zygotic transition of gene expression

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TPRXL as an antibody target. Whether an autoantibody or antibody against TPRXL could matter depends on whether native TPRXL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TPRXL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TPRXL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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