Seroatlas · Human Serome Atlas

TPRX2

Tetrapeptide repeat homeobox protein 2

Also known as: TPRX2_HUMAN, TPRX2P, TPRX2P1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DV77
Gene: TPRX2
Ensembl: ENSG00000259009
Chromosome: 19
Canonical length: 301 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This pseudogene is a member of the TPRX homeobox gene family. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

301 residues, UniProt reviewed canonical sequence.

>P0DV77|TPRX2
     1  MQDPGHLQGP PLALDPPRRQ RQERTVYTES QQKVLEFYFQ KDQYPNYDQR LNLAEMLSLR
    61  EQQLQVWFKN RRAKLARERR LQQQPQRVPG QRGRGARAAP LVPVAAASFP GGPEFPQGRG
   121  SWISPQPGPW GVLPAAEPKI YSLPRTWGGP ECGTQEGLKA VPAPGPGPIP APIPGPAQIP
   181  GPVPGPAPNL GPMSGPLSVS IPGPIPAPIS CPGPIPDPVL GRTLMPGPGS LPTPAPGALW
   241  PQSPYASNLS PDTQLYPDFT KLLPLLDRFE ESSLSTTTSQ YKEEDGFVDK NHSVPRSLLD
   301  L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TPRX2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 0.6 nTPM

Expression across tissuesHPA

Tissue

retina: 0.6 nTPM
skin: 0.1 nTPM
testis: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
appendix: 0 nTPM

Single-cell type

undifferentiated spermatogonia: 0.2 nCPM
differentiating spermatogonia: 0.1 nCPM
retinal bipolar cells: 0.1 nCPM
rod photoreceptor cells: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.3 nTPM
basal ganglia: 0.2 nTPM
cerebellum: 0.2 nTPM
amygdala: 0.1 nTPM
hippocampal formation: 0.1 nTPM
medulla oblongata: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.55
gnomAD pLI: 0.06

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TPRX2 as an antibody target. Whether an autoantibody or antibody against TPRX2 could matter depends on whether native TPRX2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TPRX2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TPRX2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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