Seroatlas · Human Serome Atlas

TPRX1

Tetra-peptide repeat homeobox protein 1

Also known as: TPRX1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N7U7
Gene: TPRX1
Canonical length: 411 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for TPRX1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

411 residues, UniProt reviewed canonical sequence.

>Q8N7U7|TPRX1
     1  MLSLREQQLQ VWFKNRRAKL ARERRLQQQP QRVPGQRGRG ARAAPLVPAA SASAPQRGPS
    61  GILPAAEPTI CSLHQAWGGP GCRAQKGIPA ALSPGPGPIP APIPGPAQIP GPLPGSIPGP
   121  IPGPAQIPSP IPAPIPGPIS GPVQIPGPFR GPIPGPISGP APIPGPISGP FSGPNPGPIP
   181  GPNPGPIPGP ISGPIPGPIS VPIPGPIPGP ISGPISGPNP GPIPGPIPGP ISGPNPGPIP
   241  GPISGPNPGL IPGPIPGPIS GPGPIIGPIP SPAQIPGPGR LQGPGPILSP GRMRSPGSLP
   301  GLAPILGPGS GPGSGSVPAP IPGPGSLPAP APLWPQSPDA SDFLPDTQLF PHFTELLLPL
   361  DPLEGSSVST MTSQYQEGDD SMGKKHSGSQ PQEEGGSVNE NHSGPRLLLD L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TPRX1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 1.1 nTPM

Expression across tissuesHPA

Tissue

testis: 1.1 nTPM
retina: 1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

rod photoreceptor cells: 12 nCPM
retinal ganglion cells: 3.9 nCPM
epididymal principal cells: 2.7 nCPM
thymic myoid cells: 2.7 nCPM
early primary spermatocytes: 2.4 nCPM
retinal bipolar cells: 2.3 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 1.1 nTPM
cerebral cortex: 1 nTPM
hippocampal formation: 0.8 nTPM
amygdala: 0.3 nTPM
basal ganglia: 0.3 nTPM
choroid plexus: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.8
gnomAD pLI: 0.36
gnomAD missense Z: -0.34
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

maternal-to-zygotic transition of gene expression

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TPRX1 as an antibody target. Whether an autoantibody or antibody against TPRX1 could matter depends on whether native TPRX1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TPRX1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TPRX1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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