Seroatlas · Human Serome Atlas

TPRG1L

Tumor protein p63-regulated gene 1-like protein

Also known as: FAM79A, FLJ21811, h-Mover, RP11-46F15.3, SVAP30, TPRGL, TPRGL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5T0D9
Gene
TPRG1L
Ensembl
ENSG00000158109
Chromosome
1
Canonical length
272 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles,Plasma membrane
Quaternary structure
Homomultimer

OverviewNCBI Gene

Predicted to enable calmodulin binding activity and identical protein binding activity. Predicted to be involved in presynaptic modulation of chemical synaptic transmission; regulation of glutamatergic synaptic transmission; and regulation of synaptic vesicle exocytosis. Predicted to act upstream of or within calcineurin-NFAT signaling cascade; negative regulation of synaptic transmission; and synaptic vesicle docking. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

272 residues, UniProt reviewed canonical sequence.

>Q5T0D9|TPRG1L
     1  MLQLRDSVDS AGTSPTAVLA AGEEVGAGGG PGGGRPGAGT PLRQTLWPLS IHDPTRRARV
    61  KEYFVFRPGS IEQAVEEIRV VVRPVEDGEI QGVWLLTEVD HWNNEKERLV LVTEQSLLIC
   121  KYDFISLQCQ QVVRIALNAV DTISYGEFQF PPKSLNKREG FGIRIQWDKQ SRPSFINRWN
   181  PWSTNVPYAT FTEHPMAGAD EKTASLCQLE SFKALLIQAV KKAQKESPLP GQANGVLILE
   241  RPLLIETYVG LMSFINNEAK LGYSMTRGKI GF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TPRG1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
101 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 101 nTPM
  • basal ganglia: 84 nTPM
  • liver: 83 nTPM
  • amygdala: 74 nTPM
  • hippocampal formation: 72 nTPM
  • hypothalamus: 68 nTPM

Single-cell type

  • esophageal apical cells: 81 nCPM
  • platelets: 79 nCPM
  • hepatocytes: 68 nCPM
  • retinal horizontal cells: 68 nCPM
  • colonocytes: 59 nCPM
  • enterocytes: 58 nCPM

Immune cell

  • basophil: 21 nTPM
  • neutrophil: 19 nTPM
  • plasmacytoid DC: 8.9 nTPM
  • MAIT T-cell: 7.6 nTPM
  • naive CD8 T-cell: 7.2 nTPM
  • memory CD4 T-cell: 6.7 nTPM

Brain region

  • cerebral cortex: 122 nTPM
  • pons: 112 nTPM
  • basal ganglia: 108 nTPM
  • hypothalamus: 106 nTPM
  • hippocampal formation: 105 nTPM
  • medulla oblongata: 94 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.49
gnomAD pLI
0
gnomAD missense Z
0.78
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TPRG1L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TPRG1L as an antibody target. Whether an autoantibody or antibody against TPRG1L could matter depends on whether native TPRG1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TPRG1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TPRG1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TPRG1L. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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