Seroatlas · Human Serome Atlas

TPRG1

Tumor protein p63-regulated gene 1 protein

Also known as: FAM79B, FLJ41238, FLJ43694, TPRG1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZUI0
Gene: TPRG1
Ensembl: ENSG00000188001
Chromosome: 3
Canonical length: 275 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

275 residues, UniProt reviewed canonical sequence.

>Q6ZUI0|TPRG1
     1  MSTIGSFEGF QAVSLKQEGD DQPSETDHLS MEEEDPMPRQ ISRQSSVTES TLYPNPYHQP
    61  YISRKYFATR PGAIETAMED LKGHVAETSG ETIQGFWLLT KIDHWNNEKE RILLVTDKTL
   121  LICKYDFIML SCVQLQRIPL SAVYRICLGK FTFPGMSLDK RQGEGLRIYW GSPEEQSLLS
   181  RWNPWSTEVP YATFTEHPMK YTSEKFLEIC KLSGFMSKLV PAIQNAHKNS TGSGRGKKLM
   241  VLTEPILIET YTGLMSFIGN RNKLGYSLAR GSIGF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TPRG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 49 nTPM

Expression across tissuesHPA

Tissue

esophagus: 49 nTPM
vagina: 32 nTPM
cervix: 28 nTPM
skin: 24 nTPM
breast: 22 nTPM
adipose tissue: 9.8 nTPM

Single-cell type

esophageal apical cells: 2,785 nCPM
adipocytes: 752 nCPM
myosatellite cells: 423 nCPM
kupffer cells: 365 nCPM
hepatocytes: 326 nCPM
late primary spermatocytes: 232 nCPM

Immune cell

memory CD8 T-cell: 4 nTPM
gdT-cell: 3.8 nTPM
T-reg: 3.8 nTPM
memory CD4 T-cell: 3 nTPM
classical monocyte: 1.5 nTPM
naive CD8 T-cell: 1.5 nTPM

Brain region

thalamus: 8.6 nTPM
choroid plexus: 7.9 nTPM
medulla oblongata: 5.2 nTPM
white matter: 4.9 nTPM
hypothalamus: 3.6 nTPM
pons: 2.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.72
gnomAD pLI: 0
gnomAD missense Z: -0.48
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Cytoplasm

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TPRG1 as an antibody target. Whether an autoantibody or antibody against TPRG1 could matter depends on whether native TPRG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TPRG1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TPRG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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