Seroatlas · Human Serome Atlas

TPPP3

Tubulin polymerization-promoting protein family member 3

Also known as: CGI-38, p20, p25gamma, TPPP3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BW30
Gene: TPPP3
Ensembl: ENSG00000159713
Chromosome: 16
Canonical length: 176 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables tubulin binding activity. Involved in decidualization and microtubule bundle formation. Located in microtubule bundle and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

176 residues, UniProt reviewed canonical sequence.

>Q9BW30|TPPP3
     1  MAASTDMAGL EESFRKFAIH GDPKASGQEM NGKNWAKLCK DCKVADGKSV TGTDVDIVFS
    61  KVKGKSARVI NYEEFKKALE ELATKRFKGK SKEEAFDAIC QLVAGKEPAN VGVTKAKTGG
   121  AVDRLTDTSR YTGSHKERFD ESGKGKGIAG RQDILDDSGY VSAYKNAGTY DAKVKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TPPP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 808 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 808 nTPM
spinal cord: 320 nTPM
hypothalamus: 276 nTPM
hippocampal formation: 257 nTPM
midbrain: 217 nTPM
amygdala: 204 nTPM

Single-cell type

epididymal efferent duct ciliated cells: 2,222 nCPM
fallopian tube ciliated cells: 1,942 nCPM
respiratory ciliated cells: 1,873 nCPM
endometrial ciliated cells: 1,038 nCPM
melanocytes: 506 nCPM
suprabasal keratinocytes: 298 nCPM

Immune cell

non-classical monocyte: 66 nTPM
intermediate monocyte: 38 nTPM
myeloid DC: 33 nTPM
classical monocyte: 25 nTPM
eosinophil: 13 nTPM
total PBMC: 9.4 nTPM

Brain region

midbrain: 364 nTPM
white matter: 356 nTPM
medulla oblongata: 301 nTPM
hypothalamus: 222 nTPM
spinal cord: 218 nTPM
pons: 209 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.99
gnomAD pLI: 0.37
gnomAD missense Z: 0.88
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

tubulin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TPPP3 as an antibody target. Whether an autoantibody or antibody against TPPP3 could matter depends on whether native TPPP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TPPP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TPPP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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