Seroatlas · Human Serome Atlas

TPPP2

Tubulin polymerization-promoting protein family member 2

Also known as: C14orf8, CT152, p18, p25beta, TPPP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P59282
Gene: TPPP2
Ensembl: ENSG00000179636
Chromosome: 14
Canonical length: 170 aa
Protein class: Predicted intracellular proteins
Subcellular location: Connecting piece,Mid piece,Principal piece

OverviewNCBI Gene

Enables tubulin binding activity. Involved in regulation of flagellated sperm motility. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

170 residues, UniProt reviewed canonical sequence.

>P59282|TPPP2
     1  MASEAEKTFH RFAAFGESSS SGTEMNNKNF SKLCKDCGIM DGKTVTSTDV DIVFSKVKAK
    61  NARTITFQQF KEAVKELGQK RFKGKSPDEV LENIYGLMEG KDPATTGATK ATTVGAVDRL
   121  TDTSKYTGTH KERFDESGKG KGIAGREEMT DNTGYVSGYK GSGTYDKKTK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TPPP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 251 nTPM

Expression across tissuesHPA

Tissue

testis: 251 nTPM
liver: 12 nTPM
tongue: 4.4 nTPM
epididymis: 3.2 nTPM
skeletal muscle: 3 nTPM
choroid plexus: 1.8 nTPM

Single-cell type

late spermatids: 16,491 nCPM
early spermatids: 2,213 nCPM
late primary spermatocytes: 445 nCPM
hepatocytes: 37 nCPM
epididymal principal cells: 30 nCPM
leydig cells: 24 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 1.6 nTPM
medulla oblongata: 0.8 nTPM
spinal cord: 0.8 nTPM
basal ganglia: 0.7 nTPM
cerebral cortex: 0.7 nTPM
pons: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.41
gnomAD pLI: 0.02
gnomAD missense Z: -0.24
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

tubulin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TPPP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CFAP65

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TPPP2 as an antibody target. Whether an autoantibody or antibody against TPPP2 could matter depends on whether native TPPP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TPPP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TPPP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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