Seroatlas · Human Serome Atlas

TPBGL

Trophoblast glycoprotein-like

Also known as: TPBGL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DKB5
Gene: TPBGL
Ensembl: ENSG00000261594
Chromosome: 11
Canonical length: 382 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

382 residues, UniProt reviewed canonical sequence.

>P0DKB5|TPBGL
     1  MAPRAGQPGL QGLLLVAAAL SQPAAPCPFQ CYCFGGPKLL LRCASGAELR QPPRDVPPDA
    61  RNLTIVGANL TVLRAAAFAG GDGDGDQAAG VRLPLLSALR LTHNHIEVVE DGAFDGLPSL
   121  AALDLSHNPL RALGGGAFRG LPALRSLQLN HALVRGGPAL LAALDAALAP LAELRLLGLA
   181  GNALSRLPPA ALRLARLEQL DVRLNALAGL DPDELRALER DGGLPGPRLL LADNPLRCGC
   241  AARPLLAWLR NATERVPDSR RLRCAAPRAL LDRPLLDLDG ARLRCADSGA DARGEEAEAA
   301  GPELEASYVF FGLVLALIGL IFLMVLYLNR RGIQRWMRNL REACRDQMEG YHYRYEQDAD
   361  PRRAPAPAAP AGSRATSPGS GL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TPBGL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 4.1 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 4.1 nTPM
testis: 4.1 nTPM
cerebral cortex: 2.9 nTPM
amygdala: 2 nTPM
adrenal gland: 1.5 nTPM
hippocampal formation: 1.4 nTPM

Single-cell type

retinal bipolar cells: 14 nCPM
müller glia: 11 nCPM
epididymal efferent duct absorptive cells: 4.2 nCPM
melanocytes: 4.2 nCPM
retinal horizontal cells: 2 nCPM
sertoli cells: 2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 25 nTPM
cerebral cortex: 11 nTPM
basal ganglia: 10 nTPM
amygdala: 6.6 nTPM
white matter: 4.1 nTPM
pons: 4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.62
gnomAD pLI: 0.43
gnomAD missense Z: 0.03
DepMap mean gene effect: -0.11
DepMap dependency class: selective

OntologyGO

Biological processes

negative regulation of canonical Wnt signaling pathway

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TPBGL as an antibody target. Whether an autoantibody or antibody against TPBGL could matter depends on whether native TPBGL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TPBGL is annotated at the cell surface, where native TPBGL is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TPBGL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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