TPBG

Protein identityUniProt · HPA

UniProt accession

Q13641

Gene

TPBG

Ensembl

ENSG00000146242

Chromosome

6

Canonical length

420 aa

Protein class

Predicted membrane proteins

Subcellular location

Nucleoplasm

OverviewNCBI Gene

This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

420 residues, UniProt reviewed canonical sequence.

>Q13641|TPBG
     1  MPGGCSRGPA AGDGRLRLAR LALVLLGWVS SSSPTSSASS FSSSAPFLAS AVSAQPPLPD
    61  QCPALCECSE AARTVKCVNR NLTEVPTDLP AYVRNLFLTG NQLAVLPAGA FARRPPLAEL
   121  AALNLSGSRL DEVRAGAFEH LPSLRQLDLS HNPLADLSPF AFSGSNASVS APSPLVELIL
   181  NHIVPPEDER QNRSFEGMVV AALLAGRALQ GLRRLELASN HFLYLPRDVL AQLPSLRHLD
   241  LSNNSLVSLT YVSFRNLTHL ESLHLEDNAL KVLHNGTLAE LQGLPHIRVF LDNNPWVCDC
   301  HMADMVTWLK ETEVVQGKDR LTCAYPEKMR NRVLLELNSA DLDCDPILPP SLQTSYVFLG
   361  IVLALIGAIF LLVLYLNRKG IKKWMHNIRD ACRDHMEGYH YRYEINADPR LTNLSSNSDV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TPBG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.37

Highest tissue expression

33 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TPBG.

Disease | ImmuneIEDB

Conditions an epitope on TPBG was assayed in.

• colorectal cancer T cell
• clear cell renal cell carcinoma T cell
• kidney clear cell sarcoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.16

gnomAD pLI

0.01

gnomAD missense Z

0.07

DepMap mean gene effect

0.09

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell adhesion
• cell chemotaxis
• dendrite arborization
• mesenchymal cell migration
• negative regulation of canonical Wnt signaling pathway
• negative regulation of cell population proliferation
• olfactory learning
• positive regulation of chemotaxis
• positive regulation of ERK1 and ERK2 cascade
• positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
• positive regulation of synapse assembly
• protein localization to plasma membrane
• synaptic transmission, GABAergic

Cellular components

• axon terminus
• cell surface
• dendrite
• endoplasmic reticulum
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Leucine-rich repeat N-terminal domain
• Cysteine-rich flanking region, C-terminal
• Leucine-rich repeat
• Leucine-rich repeat, typical subtype
• Leucine-rich repeat domain superfamily
• Wnt/beta-catenin signaling inhibitor
• Leucine rich repeat N-terminal domain
• Leucine rich repeat C-terminal domain
• Leucine rich repeat

KeywordsUniProt

• Cell membrane
• Disulfide bond
• Glycoprotein
• Leucine-rich repeat
• Membrane
• Phosphoprotein
• Repeat
• Signal
• Transmembrane
• Transmembrane helix