TP53TG5
TP53-target gene 5 protein
Also known as: C20orf10, CLG01, dJ453C12.5, T53G5_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9Y2B4
- Gene
- TP53TG5
- Ensembl
- ENSG00000124251
- Chromosome
- 20
- Canonical length
- 290 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoli,Nucleoli rim,Mitotic chromosome
OverviewNCBI Gene
Predicted to be involved in intracellular signal transduction and negative regulation of cell growth. Located in chromosome and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
290 residues, UniProt reviewed canonical sequence.
>Q9Y2B4|TP53TG5
1 MSPSAKKRPK NSRVSKMQDE KLRDETEQPV SKVIERNRLR TVLKNLSLLK LLKSSNRRIQ
61 ELHKLAKRCW HSLLSVPKIL RISSGENSAC NKTKQNNEEF QEIGCSEKEL KSKKLESTGD
121 PKKKEYKEWK SQVQSGMRNK EKTSLAAMPR KEKHIEPEVP RTSRDDSLNP GVQGRQPLTE
181 GPRVIFIKPY RNRTPMGHMK QLDVADQWIW FEGLPTRIHL PAPRVMCRSS TLRWVKRRCT
241 RFCSASLEMP MWHPYKVDVT WTRARGASRG WRSRHQLKGR NGWRNSRVYKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TP53TG5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.67
- Highest tissue expression
- 17 nTPM
Expression across tissuesHPA
Tissue
- testis: 17 nTPM
- spinal cord: 3 nTPM
- midbrain: 2 nTPM
- hippocampal formation: 1.8 nTPM
- basal ganglia: 1.1 nTPM
- amygdala: 1 nTPM
Single-cell type
- early spermatids: 1,009 nCPM
- late spermatids: 326 nCPM
- oligodendrocytes: 195 nCPM
- epicardial cells: 146 nCPM
- cardiomyocytes: 145 nCPM
- bergmann glia: 48 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- white matter: 9.8 nTPM
- pons: 7 nTPM
- cerebral cortex: 6.7 nTPM
- medulla oblongata: 6.7 nTPM
- basal ganglia: 6.4 nTPM
- thalamus: 6.4 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.35
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.49
- DepMap mean gene effect
- 0.1
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
- TP53-target gene 5 protein
- Cellular tumour antigen p53-inducible 5
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TP53TG5 as an antibody target. Whether an autoantibody or antibody against TP53TG5 could matter depends on whether native TP53TG5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TP53TG5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TP53TG5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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