Seroatlas · Human Serome Atlas

TP53TG3

TP53-target gene 3 protein

Also known as: P53TG3, T53G3_HUMAN, TP53TG3A, TP53TG3B, TP53TG3C, TP53TG3D, TP53TG3E, TP53TG3F

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9ULZ0
Gene
TP53TG3
Ensembl
ENSG00000183632
Chromosome
16
Canonical length
124 aa
Protein class
Predicted intracellular proteins
Subcellular location
Centriolar satellite

OverviewNCBI Gene

Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

124 residues, UniProt reviewed canonical sequence.

>Q9ULZ0|TP53TG3
     1  MRASPCISQP AASWHPRPSA LRPTAGSGPD TRTPGTVEDG SAPCPAFRSP AVSPCGEEPC
    61  CFQISPAEET LELGRLVSPG NCDTLSPRAA GFYACHVRSL IPCRSTKGRW PLTASAAGLS
   121  SFSG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TP53TG3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.74
Highest tissue expression
6.5 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 6.5 nTPM
  • testis: 3.4 nTPM
  • adrenal gland: 0.3 nTPM
  • placenta: 0.3 nTPM
  • cerebellum: 0.2 nTPM
  • adipose tissue: 0.1 nTPM

Single-cell type

  • early primary spermatocytes: 0.1 nCPM
  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • thalamus: 0.5 nTPM
  • midbrain: 0.4 nTPM
  • pons: 0.4 nTPM
  • white matter: 0.4 nTPM
  • cerebellum: 0.3 nTPM
  • medulla oblongata: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.83
gnomAD pLI
0.01

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TP53TG3 as an antibody target. Whether an autoantibody or antibody against TP53TG3 could matter depends on whether native TP53TG3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TP53TG3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TP53TG3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TP53TG3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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